| ncRNA name | rno-miR-7 |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinal endothelial cells, retinal pericytes |
| Methods | qRT-PCR, Western blot, transfection, CCK-8 assay, luciferase reporter assay |
| Expression pattern | down-regulated |
| Functional description | miR-7 was lowly expressed in ECs and RPs cells. Overexpression of miR-7 can down-regulate the expression levels of PI3K, AKT, and VEGF by down-regulating its downstream target gene IRS-1, and ultimately inhibit the proliferation of retinal cells. |
| PubMed ID | 30058674 |
| Year | 2018 |
| Title | MiR-7 regulates the PI3K/AKT/VEGF pathway of retinal capillary endothelial cell and retinal pericytes in diabetic rat model through IRS-1 and inhibits cell proliferation. |
| Drug-related ncRNA | NO |
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